INTRODUCTION Patients with decompensated cirrhosis and hyponatremia have a poor prognosis. We investigated Albumin to Prevent Infection in Chronic Liver Failure trial data to determine whether targeted albumin infusions improved outcome in patients with hyponatremia at baseline. METHODS We examined the interaction between targeted albumin and standard care for the composite primary end point, stratifying by baseline sodium ≥ and <130 mmol/L. RESULTS Randomization to albumin was associated with a significant increase in sodium; however, there was no interaction between sodium category and treatment for the trial primary end point. DISCUSSION Targeted intravenous albumin infusions increased serum sodium level in hospitalized hyponatremic patients with cirrhosis, but this did not improve outcome.

中文翻译：

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靶向白蛋白治疗不能改善因肝硬化并发症住院的低钠血症患者的短期预后：来自 ATTIRE 试验的数据。

引言 失代偿期肝硬化和低钠血症患者预后较差。我们调查了白蛋白预防慢性肝衰竭感染的试验数据，以确定靶向白蛋白输注是否能改善基线低钠血症患者的预后。方法我们检查了靶向白蛋白和标准治疗之间的相互作用，以达到复合主要终点，按基线钠 ≥ 和 < 130 mmol/L 进行分层。结果 白蛋白的随机化与钠的显着增加有关；然而，钠类别与试验主要终点的治疗之间没有相互作用。讨论 有针对性的静脉白蛋白输注提高了住院低钠血症肝硬化患者的血清钠水平，但这并没有改善结果。