We communicate two mild, solvent-free mechanochemical coupling transformations of CF₃ group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C−F bond activation, accompanied with utilisation of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF₃ group into other functionalities.

中文翻译：

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CF3 基团的机械化学转化：酰胺和席夫碱的合成

我们使用 Ytterbia 作为催化剂，将 CF ₃基团与硝基化合物的两种温和、无溶剂机械化学偶联转化为酰胺或席夫碱。该过程通过 C-F 键活化进行，同时使用基于硅的还原剂/氧清除剂——硝基的还原剂。对所公开的方法的范围和限制进行了彻底的研究。据我们所知，这项工作是机械能促进惰性 CF ₃基团转化为其他功能的第一个例子。