Mitochondria are dynamic, interactive organelles that connect cellular signaling and whole-cell homeostasis. This “mitochatting” allows the cell to receive information about the mitochondria’s condition before accommodating energy demands. Mitofusin 2 (Mfn2), an outer mitochondrial membrane fusion protein specializes in mediating mitochondrial homeostasis. Early studies defined the biological significance of Mfn2, while latter studies highlighted its role in substrate metabolism. However, determining Mfn2 potential to contribute to energy homeostasis needs study. This review summarizes current literature on mitochondrial metabolic processes, dynamics, and evidence of interactions among Mfn2 and regulatory processes that may link Mfn2’s role in maintaining mitochondrial function and substrate metabolism.

线粒体是连接细胞信号传导和全细胞稳态的动态、交互式细胞器。这种“线粒体”允许细胞在满足能量需求之前接收有关线粒体状况的信息。Mitofusin 2 (Mfn2) 是一种线粒体外膜融合蛋白，专门用于介导线粒体稳态。早期研究定义了 Mfn2 的生物学意义，而后来的研究强调了它在底物代谢中的作用。然而，确定 Mfn2 有助于能量稳态的潜力需要研究。本综述总结了有关线粒体代谢过程、动力学以及 Mfn2 与调节过程之间相互作用的证据的当前文献，这些过程可能将 Mfn2 在维持线粒体功能和底物代谢中的作用联系起来。