Phytomelatonin is a pleiotropic molecule that originated in higher plants with many diverse actions and is primarily an antioxidant. The recent identification and advancement of phytomelatonin unraveled the potential of this modulatory molecule being considered a new plant hormone, suggesting its relevance in treating respiratory infections, including COVID-19. Besides, this molecule is also involved in multiple hormonal, physiological, and biological processes at different levels of cell organization and has been marked for its ability to cross the blood-brain barrier and prominent antioxidant effects, reducing mitochondrial electron leakage, up-regulating antioxidant enzymes, acting as a free radical scavenger, and interfering with pro-inflammatory signaling pathways as seen in mood swings, body temperature, sleep, cancer, cardiac rhythms, and immunological regulation modulators. However, due to its diversity, availability, affordability, convenience, and high safety profile, phytomelatonin has also been suggested as a natural adjuvant. This review discussed the origin, content in various plant species, processes of extraction, and detection and therapeutic potentials of phytomelatonin in treating COVID-19-exposed individuals.

植物褪黑素是一种多效性分子，起源于高等植物，具有多种不同的作用，主要是一种抗氧化剂。植物褪黑素的最新发现和进展揭示了这种调节分子被视为新植物激素的潜力，表明其在治疗呼吸道感染（包括 COVID-19）方面的相关性。此外，该分子还参与细胞组织不同层面的多种激素、生理和生物过程，并以其穿越血脑屏障的能力和显着的抗氧化作用、减少线粒体电子泄漏、上调抗氧化作用而闻名。酶，作为自由基清除剂，干扰情绪波动、体温、睡眠、癌症、心律和免疫调节调节剂中的促炎信号传导途径。然而，由于其多样性、可用性、可负担性、便利性和高安全性，植物褪黑素也被建议作为天然佐剂。这篇综述讨论了植物褪黑素的起源、不同植物物种中的含量、提取过程以及植物褪黑素在治疗 COVID-19 暴露个体中的检测和治疗潜力。