In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were characterized by elemental analysis, FT-IR, LC-MS, ¹H NMR, and ¹³C{¹H} NMR spectroscopy. These new N-heterocyclic carbene precursors and Ag(I)-NHC complexes were evaluated for their antibacterial, antifungal, and antibiofilm activities. The biological activities of synthesized products were compared with standard drugs. All compounds have moderate antibacterial and antibiofilm activities. In particular, while compound 2a was found to be the best inhibitor of E. coli biofilms, while compound 2d inhibited C. albicans biofilm at the highest rate. All the compounds were also analyzed by molecular docking methods with the certain target molecules.

在这项研究中，我们报道了一系列新的银 (I)-N-杂环卡宾配合物的合成，这些配合物是从相应的新 N-杂环卡宾 (NHC) 前体中获得的。所有新化合物均通过元素分析、FT-IR、LC-MS、¹ H NMR 和¹³ C{ ¹ H} NMR 光谱进行表征。评估了这些新的 N-杂环卡宾前体和 Ag(I)-NHC 复合物的抗菌、抗真菌和抗生物膜活性。合成产物的生物活性与标准药物进行了比较。所有化合物都具有中等的抗菌和抗生物膜活性。特别是，虽然发现化合物2a是大肠杆菌生物膜的最佳抑制剂，而化合物2d以最高速率抑制白色念珠菌生物膜。所有化合物还通过分子对接方法与某些目标分子进行了分析。