The chiral β-amino alcohols are widely presented in the natural products, privileged ligands, and medicinal molecules. In the past decades, the construction of anti-β-amino alcohols have attracted in the interest of synthetic chemists. A number of studies indicated that the chelation-controlled hydride reduction approach is straightforward for the preparation of anti-β-amino alcohol motifs in high yield with excellent diastereoselectivity and they can be used as chiral building block in the total synthesis of natural products and medicinal molecules. The aim of this review is to highlight application of chelation-controlled hydride reduction in total synthesis of natural products and medicinal molecules on the basis of a collection of recent literature studies.

中文翻译：

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氨基酮的螯合控制非对映选择性氢化物还原全合成天然产物和药物分子

手性β-氨基醇广泛存在于天然产物、特权配体和药物分子中。在过去的几十年中，抗-β-氨基醇的构建引起了合成化学家的兴趣。大量研究表明，螯合控制的氢化物还原方法可直接以高产率制备抗-β-氨基醇基序，具有优异的非对映选择性，可作为天然产物和药物全合成的手性构件。分子。本综述的目的是在最近收集的文献研究的基础上，强调螯合控制氢化物还原在天然产物和药物分子的全合成中的应用。