To investigate the effect of astragalus heart-protecting decoction on rats with dilated cardiomyopathy (DCM). 36 healthy rats were divided into normal control group (n = 12, unmodeled rats without receiving decoction), DCM + control group (n = 12, modeled rats without decoction), and DCM + treatment group (n = 12, modeled rats receiving decoction). Outcomes of the three groups were compared. Serum brain natriuretic peptide and matrix metallopeptidase 10, ventricular remodeling indicators, whole heart weight index and left ventricular weight index were significantly lower in normal control group than in the DMC + treatment and DMC + control groups, so was that in DMC + treatment group compared with those in DMC + control group (P < 0.05). Additionally, the normal control group had higher superoxide dismutase level but lower malondialdehyde and lactate dehydrogenase levels than the DMC + treatment and DMC + control groups (P < 0.05). Regarding myocardial histology or myocardial fibrosis, the DMC + treatment group highlighted better performance than the DMC + control group, with differences from those in the normal control group though. Astragalus heart-protecting decoction has a positive effect in the treatment of rats with DCM.

探讨黄芪护心汤对扩张型心肌病（DCM）大鼠的影响。36只健康大鼠分为正常对照组（n=12，未灌汤未造模大鼠）、DCM+对照组（n=12，未灌汤造模大鼠）、DCM+治疗组（n=12，未灌汤造模大鼠） ）。比较三组的结果。正常对照组血清脑钠肽和基质金属肽酶10、心室重构指标、全心重量指数和左心室重量指数均显着低于DMC+治疗组和DMC+对照组，DMC+治疗组也明显低于DMC+治疗组。与DMC+对照组（P < 0.05)。此外，正常对照组超氧化物歧化酶水平高于DMC+处理组和DMC+对照组，但丙二醛和乳酸脱氢酶水平低于DMC+处理组（P  < 0.05）。在心肌组织学或心肌纤维化方面，DMC+治疗组表现优于DMC+对照组，但与正常对照组存在差异。黄芪护心汤治疗DCM大鼠有积极作用。