Effects of stannum (Sn) addition on corrosion behavior and biocompatibility in vitro of biodegradable Zn–Sn alloys,Materials and Corrosion

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Effects of stannum (Sn) addition on corrosion behavior and biocompatibility in vitro of biodegradable Zn–Sn alloys
Materials and Corrosion ( IF 1.6 ) Pub Date : 2021-09-15 , DOI: 10.1002/maco.202112722
Pushan Guo ₁ , Robabeh Bagheri ₂ , Lijing Yang ₂ , Zhenlun Song ₂ , Yaxuan Liu ₁

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Zinc (Zn) and its alloys, as novel biodegradable metals, hold great potential in bone implant and metallic stents. Stannum (Sn), an essential trace element, plays an important role in maintaining life activities. Herein, Sn is selected as an alloying element to be added into the Zn matrix to explore the possibility of Zn–Sn alloy as a biodegradable metal for clinical application. This article systemically studies the effects of Sn content on microstructural, electrochemical behavior, corrosion rate, and in vitro biocompatibility of Zn–Sn alloys. Results indicate that the Sn-rich phase is the main form of Sn in the as-extruded alloys, and the solid solubility is in an extremely minute quantity. The corrosion of Zn–Sn alloys in conventional simulated body fluid (c-SBF) solution shows apparent electrochemical characteristics, and Sn-rich phases are corroded preferably. The corrosion rates of Zn–1.0Sn and Zn–2.0Sn are under 0.2 mm year⁻¹, which can satisfy the requirement of biodegradable medical materials. In addition, Zn–1.0Sn exhibits much better cytocompatibility and hemocompatibility than Zn–2.0Sn. Therefore, Zn–Sn alloy shows great potential applications in the biological field and can be further studied and developed.

中文翻译：

添加锡 (Sn) 对可生物降解 Zn-Sn 合金体外腐蚀行为和生物相容性的影响

锌（Zn）及其合金作为新型可生物降解金属，在骨植入物和金属支架中具有巨大的潜力。锡（Sn）是人体必需的微量元素，在维持生命活动中起着重要作用。在此，选择 Sn 作为合金元素添加到 Zn 基体中，以探索 Zn-Sn 合金作为可生物降解金属用于临床应用的可能性。本文系统研究了Sn含量对Zn-Sn合金的微观结构、电化学行为、腐蚀速率和体外生物相容性的影响。结果表明，富Sn相是挤压态合金中Sn的主要形态，固溶度极微。Zn-Sn合金在常规模拟体液（c-SBF）溶液中的腐蚀表现出明显的电化学特性，优选腐蚀富Sn相。Zn–1.0Sn 和 Zn–2.0Sn 的腐蚀速率在 0.2 mm/年以下^-1，可满足生物降解医用材料的要求。此外，Zn-1.0Sn 表现出比 Zn-2.0Sn 更好的细胞相容性和血液相容性。因此，Zn-Sn合金在生物领域显示出巨大的应用潜力，可以进一步研究和开发。

更新日期：2021-09-15

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