The chemical investigation of the CH₂Cl₂/MeOH (1:1) extract from the aerial part of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) resulted in the isolation of sixteen known compounds (1–16) distributed in coumarins, flavonoid glucosides, quinic acid derivatives, triterpenoids, monoglycerid, steroids, tetraterpenoid and polyol. The structures of the compounds were determined by spectrometric and spectroscopic analysis including MS and NMR data followed by their comparison with reported ones in the literature. The chemophenetic significance of the isolated compounds was discussed. The crude extract and some of the isolated compounds were assessed in vitro for their antileishmanial, cytotoxic and antiplasmodial activities. The crude extract of M. erythrophylla showed moderate antileishmanial activity (IC₅₀ = 61.6 μg/mL) while the hexane soluble fraction showed good antileishmanial activity (IC₅₀ = 31.06 μg/mL) compared to the reference drug amphotericin B (IC₅₀ = 0.11 μM). Compounds 11 and 9 also exhibited potent antileishmanial activity (IC₅₀ = 53.7–52.0 μM). The crude extract as well as the ethyl acetate soluble fraction also exhibited good antiplasmodial activity (IC₅₀ = 7.43 ± 0.00 μg/mL and 14.49 ± 2.96 μg/mL respectively), while compounds 11, 15 and 16 showed weak activity with IC₅₀ > 20 μM compared to the reference drug artemisinin (IC₅₀ = 0.014 ± 0.001 μM).

从Mussaenda erythrophylla Schumach地上部分提取的 CH ₂ Cl ₂ /MeOH (1:1) 提取物的化学研究。& 托恩。（茜草科）导致的16种公知的化合物（所述隔离1 - 16）分布在香豆素，类黄酮糖苷，奎尼酸衍生物，三萜类化合物，单甘酯，类固醇，四萜和多醇。化合物的结构通过光谱和光谱分析确定，包括 MS 和 NMR 数据，然后与文献中报道的数据进行比较。讨论了分离化合物的化学表观意义。对粗提物和一些分离的化合物进行体外评估因其抗利什曼原虫、细胞毒性和抗疟原虫活性。 与参比药物两性霉素 B (IC ₅₀  = 0.11 ) 相比，红叶M. erythrophylla的粗提取物显示出中等的抗利什曼原虫活性 (IC ₅₀  = 61.6 μg/mL)，而己烷可溶部分显示出良好的抗利什曼原虫活性 (IC ₅₀ = 31.06 μg/mL)微米）。化合物11和9也表现出有效的抗利什曼原虫活性 (IC ₅₀  = 53.7–52.0 μM)。粗提取物以及乙酸乙酯可溶性部分也表现出良好的抗疟原虫活性（IC ₅₀  = 7.43 ± 0.00 μg/mL 和 14.49 ± 2.96 μg/mL），而化合物11、与 参考药物青蒿素（IC ₅₀  = 0.014 ± 0.001 μM）相比，图15和16显示出较弱的活性，IC ₅₀ > 20 μM 。