当前位置：
X-MOL 学术
›
J. Mater. Chem. B
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Phosphonate/quaternary ammonium copolymers as high-efficiency antibacterial coating for metallic substrates
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-31 , DOI: 10.1039/d1tb01676h Yaning Dong 1 , Li Liu 1 , Jin Sun 1 , Wan Peng 1 , Xiaohan Dong 1 , Yahui Gu 1 , Zhuangzhuang Ma 1 , Donglin Gan 1 , Pingsheng Liu 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-31 , DOI: 10.1039/d1tb01676h Yaning Dong 1 , Li Liu 1 , Jin Sun 1 , Wan Peng 1 , Xiaohan Dong 1 , Yahui Gu 1 , Zhuangzhuang Ma 1 , Donglin Gan 1 , Pingsheng Liu 1
Affiliation
|
Designing a coating material with efficient bactericidal property to cope with bacterial associated infections is highly desirable for metallic implants and devices. Here, we report phosphonate/quaternary ammonium copolymers, p(DEMMP-co-TMAEMA), as the new type of metal anchorable high-efficiency antibacterial coating. Seven p(DEMMP-co-TMAEMA) polymers with varied cationic components were precisely prepared via random radical polymerization. Copolymers were constructed on titanium alloy (TC4) substrates based on strong covalent bonding between the phosphonate group and metallic substrates through a one-step process as evidenced by XPS and water contact angle tests. A robust relationship between the composition of the copolymers and the bactericidal ability endowed to TC4 substrates was established. Results showed that the copolymer, with the pDEMMP content even as low as 6.3%, was able to anchor onto TC4 substrates. With the increase of cationic pTMAEMA content from 4.0 to 93.7% in the coating copolymer, the bactericidal ability endowed to the TC4 substrates was steadily increased from 39.4 to 98.8% for S. aureus and from 70.0 to 99.4% for E. coli after 8 h's of contacting. All p(DEMMP-co-TMAEMA) coating on TC4 substrates showed limited cytotoxicity to C2C12 cells. Notably, the phosphonate/quaternary amine copolymers can be easily constructed on diverse biomedical metals such as titanium (Ti), stainless steel (SS), and Ni/Cr alloys with significantly increased antibacterial performance, demonstrating the potency of the copolymer as the general high-efficiency antibacterial coating for diverse bio-metals.
中文翻译：
膦酸盐/季铵共聚物作为金属基材的高效抗菌涂层
金属植入物和装置非常需要设计一种具有有效杀菌性能的涂层材料来应对细菌相关感染。在这里，我们报告了膦酸盐/季铵共聚物p (DEMMP- co -TMAEMA) 作为新型金属可锚定的高效抗菌涂层。七种具有不同阳离子组分的p (DEMMP- co -TMAEMA) 聚合物通过以下方法精确制备无规自由基聚合。通过 XPS 和水接触角测试证明，基于膦酸盐基团和金属基材之间的强共价键通过一步工艺在钛合金 (TC4) 基材上构建共聚物。建立了共聚物的组成与赋予 TC4 底物的杀菌能力之间的稳健关系。结果表明，p DEMMP 含量甚至低至 6.3% 的共聚物能够锚定在 TC4 基材上。随着涂层共聚物中阳离子p TMAEMA 含量从 4.0% 增加到 93.7%，赋予 TC4 底物的杀菌能力稳步提高，对金黄色葡萄球菌从 39.4% 提高到 98.8%，对大肠杆菌从 70.0% 提高到 99.4%接触8小时后。TC4 底物上的所有p (DEMMP- co -TMAEMA) 涂层对 C2C12 细胞显示出有限的细胞毒性。值得注意的是，膦酸盐/季胺共聚物可以很容易地构建在钛 (Ti)、不锈钢 (SS) 和 Ni/Cr 合金等多种生物医学金属上，具有显着提高的抗菌性能，证明了该共聚物作为一般高- 适用于多种生物金属的高效抗菌涂层。
更新日期：2021-09-15
中文翻译：
膦酸盐/季铵共聚物作为金属基材的高效抗菌涂层
金属植入物和装置非常需要设计一种具有有效杀菌性能的涂层材料来应对细菌相关感染。在这里，我们报告了膦酸盐/季铵共聚物p (DEMMP- co -TMAEMA) 作为新型金属可锚定的高效抗菌涂层。七种具有不同阳离子组分的p (DEMMP- co -TMAEMA) 聚合物通过以下方法精确制备无规自由基聚合。通过 XPS 和水接触角测试证明，基于膦酸盐基团和金属基材之间的强共价键通过一步工艺在钛合金 (TC4) 基材上构建共聚物。建立了共聚物的组成与赋予 TC4 底物的杀菌能力之间的稳健关系。结果表明，p DEMMP 含量甚至低至 6.3% 的共聚物能够锚定在 TC4 基材上。随着涂层共聚物中阳离子p TMAEMA 含量从 4.0% 增加到 93.7%，赋予 TC4 底物的杀菌能力稳步提高，对金黄色葡萄球菌从 39.4% 提高到 98.8%，对大肠杆菌从 70.0% 提高到 99.4%接触8小时后。TC4 底物上的所有p (DEMMP- co -TMAEMA) 涂层对 C2C12 细胞显示出有限的细胞毒性。值得注意的是，膦酸盐/季胺共聚物可以很容易地构建在钛 (Ti)、不锈钢 (SS) 和 Ni/Cr 合金等多种生物医学金属上，具有显着提高的抗菌性能，证明了该共聚物作为一般高- 适用于多种生物金属的高效抗菌涂层。
京公网安备 11010802027423号