A biodegradable bismuth–gadolinium-based nano contrast agent for accurate identification and imaging of renal insufficiency in vivo,Inorganic Chemistry Frontiers

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A biodegradable bismuth–gadolinium-based nano contrast agent for accurate identification and imaging of renal insufficiency in vivo
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2021-08-24 , DOI: 10.1039/d1qi00878a
Jing Zhang ₁ , Kang Song ₁ , Jing Ping ₁ , Jun Du ₁ , Yun Sun _{2,

3,

4} , Jianping Zhang ₅ , Ming Qi ₅ , Yuqing Miao ₁ , Yuhao Li ₁

Affiliation

Magnetic resonance imaging (MRI) with excellent contrast for soft tissue imaging is often used for the diagnosis of kidney disorders, but its resolution is not high and requires the assistance of contrast agents. Because the retention time of small molecules in the kidneys is too short and they are metabolized quickly, it is necessary to design a nano-sized material for enhancing the imaging of the kidneys, thereby increasing its residence time and monitoring the lesion site in real time. For that, we designed and synthesized a new kind of nano dual-modal contrast agent (BiGd–PVP) with MR/CT imaging function for accurate identification and imaging of renal insufficiency in vivo. BiGd–PVP can interact with glutathione in the kidneys and slowly release water-soluble Gd³⁺ ions to enhance the MRI contrast ability. Due to their size advantage, BiGd–PVP nanomaterial can accumulate and stay in the kidneys for a longer time, and because of the degradation properties, they can also be gradually excreted from the kidneys. The metabolism of BiGd–PVP in an impaired kidney will be slower than that in a healthy kidney. Thus, taking advantage of this feature, through BiGd–PVP-mediated MR imaging, it is easy to distinguish between healthy kidneys and impaired kidneys.

中文翻译：

一种可生物降解的铋钆纳米造影剂，用于体内肾功能不全的准确识别和成像

软组织成像对比度极佳的磁共振成像（MRI）常用于肾脏疾病的诊断，但其分辨率不高，需要造影剂的辅助。由于小分子在肾脏中的停留时间太短，代谢速度快，需要设计一种纳米级材料来增强肾脏的成像效果，从而增加其停留时间，实时监测病变部位. 为此，我们设计并合成了一种具有MR/CT成像功能的新型纳米双模态造影剂（BiGd-PVP），用于在体内准确识别和成像肾功能不全。BiGd-PVP 可与肾脏中的谷胱甘肽相互作用并缓慢释放水溶性 Gd ³⁺离子增强 MRI 对比能力。由于其尺寸优势，BiGd-PVP纳米材料可以在肾脏中积累和停留更长时间，并且由于其降解特性，它们也可以逐渐从肾脏排出。BiGd-PVP 在受损肾脏中的代谢将比在健康肾脏中慢。因此，利用这一特点，通过 BiGd-PVP 介导的 MR 成像，很容易区分健康肾脏和受损肾脏。

更新日期：2021-09-15

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