Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-04 , DOI: 10.1039/d1cc03114g
Junya Obata _{1,

2} , Norifumi Kawakami ₃ , Akihisa Tsutsumi ₄ , Erika Nasu ₃ , Kenji Miyamoto ₃ , Masahide Kikkawa ₄ , Ryoichi Arai _{1,

2}

Affiliation

Supramolecular protein nanoparticles and nanocages have potential in a broad range of applications. Recently, we developed a uniform supramolecular protein nanoparticle, TIP60, symmmetrically self-assembled from fusion proteins of a pentameric Sm-like protein and a dimeric MyoX-coil domain. Herein, we report the icosahedral 60-meric structure of TIP60 solved using single-particle cryo-electron microscopy. Interestingly, the structure revealed 20 regular-triangle-like pores on the surface. TIP60 and its mutants have many modifiable sites on their exterior and interior surfaces. The TIP60 architecture will be useful in the development of biomedical and biochemical nanoparticles/nanocages for future applications.

中文翻译：

设计的超分子蛋白质纳米粒子 TIP60 的二十面体 60-meric 多孔结构

超分子蛋白质纳米粒子和纳米笼在广泛的应用中具有潜力。最近，我们开发了一种均匀的超分子蛋白质纳米颗粒 TIP60，它由五聚体 Sm 样蛋白和二聚体 MyoX 螺旋结构域的融合蛋白对称自组装而成。在此，我们报告了使用单粒子低温电子显微镜解决的 TIP60 的二十面体 60 聚体结构。有趣的是，该结构在表面显示出 20 个规则三角形状的孔。TIP60 及其突变体在其外表面和内表面有许多可修改的位点。TIP60 架构将有助于开发生物医学和生化纳米粒子/纳米笼，以供未来应用。

更新日期：2021-09-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11