Tunable multi-responsive mesoporous silica nanoparticles were prepared by post-condensation/surface modification of MCM-41 nanoparticles. Surface grafting of a poly(N,N-dimethylaminoethyl methacrylate)-based polymer containing disulfide bonds was achieved by a click reaction. Chemical modification, morphological characteristics, and textural properties of the nanoparticles were studied using multiple characterization techniques such as Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, small-angle X-ray scattering, and nitrogen adsorption/desorption behavior. The nanoparticles retained the meso-structural integrity of MCM41 and particle size < 100 nm after grafting with the polymer. The pH and redox-responsive behavior of the nanoparticles were also studied. The nanoparticles possess excellent drug-loading capacity owing to their large surface area and ‘closed gate’ mechanism of the grafted polymer chains. The release profile of doxorubicin at two different pH (7.4 and 5.5) and in the presence of dithiothreitol showed a dual response behavior. The nano drug carrier device exhibited efficient intracellular uptake in cancer cells with suitable cytotoxicity and pharmacokinetic behavior, and may therefore be considered a good candidate for cancer therapy.

通过MCM-41纳米粒子的后缩合/表面改性制备了可调多响应介孔二氧化硅纳米粒子。表面接枝poly( N , N-二甲基氨基乙基甲基丙烯酸酯）基聚合物通过点击反应获得。使用傅里叶变换红外光谱、热重分析、扫描电子显微镜、透射电子显微镜、小角度 X 射线散射和氮吸附/解吸行为等多种表征技术研究了纳米颗粒的化学改性、形态特征和结构特性. 纳米粒子在与聚合物接枝后保留了 MCM41 的细观结构完整性和粒径 < 100 nm。还研究了纳米颗粒的 pH 值和氧化还原响应行为。由于其大表面积和接枝聚合物链的“闭门”机制，纳米颗粒具有优异的载药能力。阿霉素在两种不同的 pH 值（7.4 和 5.5）下和在二硫苏糖醇存在下的释放曲线显示出双重响应行为。纳米药物载体装置在癌细胞中表现出有效的细胞内摄取，具有合适的细胞毒性和药代动力学行为，因此可能被认为是癌症治疗的良好候选者。