Self-assembly of polyhedral bilayer vesicles from Piezo ion channels,Physical Review E

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Self-assembly of polyhedral bilayer vesicles from Piezo ion channels
Physical Review E ( IF 2.2 ) Pub Date : 2021-09-15 , DOI: 10.1103/physreve.104.034410
Mingyuan Ma ₁ , Christoph A Haselwandter ₁

Affiliation

Piezo ion channels underlie many forms of mechanosensation in vertebrates and have been found to bend the membrane into strongly curved dome shapes. We develop a methodology describing the self-assembly of lipids and Piezo proteins into polyhedral bilayer vesicles. We validate this methodology for bilayer vesicles formed from bacterial mechanosensitive channels of small conductance, for which experiments found a polyhedral arrangement of proteins with snub cube symmetry and a well-defined characteristic vesicle size. On this basis, we calculate the self-assembly diagram for polyhedral bilayer vesicles formed from Piezo proteins. We find that the radius of curvature of the Piezo dome provides a critical control parameter for the self-assembly of Piezo vesicles, with high abundances of Piezo vesicles with octahedral, icosahedral, and snub cube symmetry with increasing Piezo dome radius of curvature.

中文翻译：

来自压电离子通道的多面体双层囊泡的自组装

压电离子通道是脊椎动物中多种机械感觉的基础，并且已经发现将膜弯曲成强烈弯曲的圆顶形状。我们开发了一种描述脂质和压电蛋白自组装成多面体双层囊泡的方法。我们验证了这种由小电导细菌机械敏感通道形成的双层囊泡的方法，为此，实验发现蛋白质的多面体排列具有钝立方对称性和明确定义的特征囊泡大小。在此基础上，我们计算了由压电蛋白形成的多面体双层囊泡的自组装图。我们发现压电圆顶的曲率半径为压电囊泡的自组装提供了一个关键的控制参数，具有八面体、二十面体、

更新日期：2021-09-15

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