Progress has been made in understanding coeliac disease, a relatively frequent and underappreciated immune-mediated condition that occurs in genetically predisposed individuals. However, several gaps remain in knowledge related to diagnosis and management. The gluten-free diet, currently the only available management, is not curative or universally effective (some adherent patients have ongoing duodenal injury). Unprecedented numbers of emerging therapies, including some with novel tolerogenic mechanisms, are currently being investigated in clinical trials. In March 2020, the Celiac Disease Foundation and the Society for the Study of Celiac Disease convened a consensus workshop to identify high-yield areas of research that should be prioritized. Workshop participants included leading experts in clinical practice, academia, government and pharmaceutical development, as well as representatives from patient support groups in North America. This Roadmap summarizes key advances in the field of coeliac disease and provides information on important discussions from the consensus approach to address gaps and opportunities related to the pathogenesis, diagnosis and management of coeliac disease. The morbidity of coeliac disease is often underestimated, which has led to an unmet need to improve the management of these patients. Expanded research funding is needed as coeliac disease is a potentially curable disease.

在了解乳糜泻方面取得了进展，乳糜泻是一种相对频繁且未被充分认识的免疫介导疾病，发生在有遗传倾向的个体中。然而，与诊断和管理相关的知识仍然存在一些差距。无麸质饮食是目前唯一可用的管理方法，它不能治愈或普遍有效（一些依从性患者有持续的十二指肠损伤）。目前正在临床试验中研究数量空前的新兴疗法，包括一些具有新型致耐受机制的疗法。2020 年 3 月，乳糜泻基金会和乳糜泻研究学会召开了一次共识研讨会，以确定应优先考虑的高产研究领域。研讨会参与者包括临床实践、学术界、政府和制药开发部门，以及来自北美患者支持团体的代表。本路线图总结了乳糜泻领域的主要进展，并提供了关于共识方法的重要讨论的信息，以解决与乳糜泻的发病机制、诊断和管理相关的差距和机会。乳糜泻的发病率经常被低估，这导致改善这些患者管理的需求未得到满足。由于乳糜泻是一种潜在可治愈的疾病，因此需要扩大研究经费。本路线图总结了乳糜泻领域的主要进展，并提供了关于共识方法的重要讨论的信息，以解决与乳糜泻的发病机制、诊断和管理相关的差距和机会。乳糜泻的发病率经常被低估，这导致改善这些患者管理的需求未得到满足。由于乳糜泻是一种潜在可治愈的疾病，因此需要扩大研究经费。本路线图总结了乳糜泻领域的主要进展，并提供了关于共识方法的重要讨论的信息，以解决与乳糜泻的发病机制、诊断和管理相关的差距和机会。乳糜泻的发病率经常被低估，这导致改善这些患者管理的需求未得到满足。由于乳糜泻是一种潜在可治愈的疾病，因此需要扩大研究经费。