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Platelets: a potential role in chronic respiratory diseases?
European Respiratory Review ( IF 9.0 ) Pub Date : 2021-09-15 , DOI: 10.1183/16000617.0062-2021
Mohamad Chebbo 1 , Catherine Duez 1 , Marie C Alessi 1, 2 , Pascal Chanez 1, 3 , Delphine Gras 1
Affiliation  

Platelets are small anucleate cells known for their role in haemostasis and thrombosis. In recent years, an increasing number of observations have suggested that platelets are also immune cells and key modulators of immunity. They express different receptors and molecules that allow them to respond to pathogens, and to interact with other immune cells. Platelets were linked to the pathogenesis of some inflammatory disorders including respiratory diseases such as asthma and idiopathic pulmonary fibrosis. Here, we discuss the involvement of platelets in different immune responses, and we focus on their potential role in various chronic lung diseases.



中文翻译:

血小板:在慢性呼吸道疾病中的潜在作用?

血小板是小的无核细胞,以其在止血和血栓形成中的作用而闻名。近年来,越来越多的观察表明,血小板也是免疫细胞和免疫的关键调节剂。它们表达不同的受体和分子,使它们能够对病原体做出反应,并与其他免疫细胞相互作用。血小板与一些炎症性疾病的发病机制有关,包括呼吸系统疾病,如哮喘和特发性肺纤维化。在这里,我们讨论了血小板在不同免疫反应中的作用,并重点关注它们在各种慢性肺病中的潜在作用。

更新日期:2021-09-15
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