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Development of a novel startle response task in Duchenne muscular dystrophy
medRxiv - Neurology Pub Date : 2021-09-13 , DOI: 10.1101/2021.09.06.21261840
Kate E. Maresh , Andriani Papageorgiou , Deborah Ridout , Neil A. Harrison , William Mandy , David Skuse , Francesco Muntoni

Duchenne muscular dystrophy (DMD), an X-linked childhood-onset muscular dystrophy caused by loss of the protein dystrophin, can be associated with neurodevelopmental, emotional and behavioural problems. A DMD mouse model also displays a neuropsychiatric phenotype, including increased startle responses to threat which normalise when dystrophin is restored in the brain.

中文翻译:

在杜氏肌营养不良症中开发一种新的惊吓反应任务

Duchenne 肌营养不良症 (DMD) 是一种由肌营养不良蛋白丢失引起的 X 连锁儿童期肌营养不良症,可能与神经发育、情绪和行为问题有关。DMD 小鼠模型还显示出神经精神病学表型,包括对威胁的惊吓反应增加,当肌营养不良蛋白在大脑中恢复时会恢复正常。
更新日期:2021-09-15
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