In this study, oil-in-water microemulsions (MEs) were developed and used as a stable carrier for delivery of Paeonia ostii seed oil (PSO), a fatty acid mixture (FAM), and α-linolenic acid (ALA). Dynamic light scattering (DLS) was used to measure the particle size and polydispersity index (PDI) of the ME. The effects of temperature, exposure to light, and the addition of antioxidants on the peroxide values of the loads were investigated. The MEs were composed of droplets with diameters between 15 and 35 nm and PDIs lower than 0.5, and the addition of antioxidants had no significant effect on the particle size and dispersibility. Temperature, more than light, was the factor that most significantly promoted doxidation, and the influence of the addition of different antioxidants was higher by butylated hydroxytoluene (BHT), followed by vitamin C and vitamin E. Viability and morphology of A549 human lung adenocarcinoma cells treated with MEs were studied. The three evaluated MEs caused damage to cell membrane and inhibited the growth of cancer cells in a dose-dependent manner. Data on intracellular malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in cancer cells indicated that the treatment with MEs stimulated oxidative stress response and induced oxidative damage. These findings showed the latent capacity of MEs for protection of nutritional factors and for drug delivery.

在这项研究中，开发了水包油微乳液 (ME) 并将其用作传递芍药的稳定载体种子油 (PSO)、脂肪酸混合物 (FAM) 和 α-亚麻酸 (ALA)。动态光散射 (DLS) 用于测量 ME 的粒径和多分散指数 (PDI)。研究了温度、光照和添加抗氧化剂对负载过氧化值的影响。MEs 由直径在 15 到 35 nm 之间且 PDI 小于 0.5 的液滴组成，抗氧化剂的加入对粒径和分散性没有显着影响。温度，而不是光，是最显着促进氧化的因素，添加不同抗氧化剂的影响以丁基羟基甲苯 (BHT) 更高，其次是维生素 C 和维生素 E。 A549 人肺腺癌细胞的活力和形态研究了用 ME 治疗。三种评估的 ME 对细胞膜造成损伤并以剂量依赖性方式抑制癌细胞的生长。癌细胞中细胞内丙二醛 (MDA) 含量和超氧化物歧化酶 (SOD) 活性的数据表明，MEs 治疗刺激了氧化应激反应并诱导了氧化损伤。这些发现表明 ME 具有保护营养因子和药物输送的潜在能力。