Solubility behavior of a poorly soluble drug (carvedilol) has been studied in the aqueous mixtures of a deep eutectic solvent composed of choline chloride and propylene glycol at different temperatures (293.15–313.15) K. The obtained solubility data are correlated using some of the well-known cosolvency models such as the van’t Hoff, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff, and the modified Wilson models. The accuracy of these mathematical models is investigated with the mean relative deviations of the back calculated solubility data. The apparent thermodynamic properties (i.e. Gibbs energy, enthalpy and entropy) of carvedilol in the investigated mixtures are also calculated with the van’t Hoff and Gibbs equations at T_hm.

已研究了难溶性药物（卡维地洛）在不同温度 (293.15–313.15) K 下由氯化胆碱和丙二醇组成的深共熔溶剂的水性混合物中的溶解度行为。获得的溶解度数据使用一些井进行了关联- 已知的共溶剂模型，例如 van't Hoff、混合响应面、Yalkowsky、Jouyban-Acree、Jouyban-Acree-van't Hoff 和修正的 Wilson 模型。这些数学模型的准确性通过反向计算的溶解度数据的平均相对偏差进行研究。所研究混合物中卡维地洛的表观热力学性质（即吉布斯能、焓和熵）也用范特霍夫方程和吉布斯方程在T _{hm 计算}.