Journal of Inorganic Biochemistry ( IF 3.8 ) Pub Date : 2021-09-15 , DOI: 10.1016/j.jinorgbio.2021.111605 Nataliia Shtemenko 1 , Isabel Pont 2 , Yuliia Husak 1 , Alexander Golichenko 1 , Salvador Blasco 1 , Alexander Shtemenko 1 , Enrique García-España 2
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The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), Glu (II), Phe (III) and Tyr (IV) is presented. The G–quadruplex stabilization potential was evaluated by fluorescence resonance energy transfer – melting analysis. All derivatives show specific binding to c-kit1 quadruplex, while II and IV have also strong stabilization activity to HTelo21 quadruplex. At the same time, the compounds do not show any stabilization activity for ds26 DNA, which suggests unique mechanisms of molecular DNA recognition for these complexes.
中文翻译：
簇二铼 (III) 顺式二羧酸盐与 α-氨基酸配体作为强大的选择性 G4s 粘合剂
介绍了具有 α-氨基酸残基 Asp ( I )、Glu ( II )、Phe ( III ) 和 Tyr ( IV )的四种顺式二羧酸二铼 (III) 的合成。G-四链体稳定电位通过荧光共振能量转移-熔解分析进行评估。所有衍生物都显示出与 c-kit1 四链体的特异性结合，而II和IV对 HTelo21 四链体也具有很强的稳定活性。同时，这些化合物对 ds26 DNA 没有任何稳定活性，这表明这些复合物具有独特的分子 DNA 识别机制。
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