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Ureasil–Polyether–CoFe2O4 Nanocomposites: Coupling a Drug Delivery System and Magnetic Hyperthermia
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2021-09-15 , DOI: 10.1021/acsapm.1c00496 Willian Max O. S. de Santana 1 , Sébastien Abramson 2 , Rodolfo Fini 1 , Bruno L. Caetano 1, 2, 3 , Christine Ménager 2 , Sandra H. Pulcinelli 1 , Celso V. Santilli 1
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2021-09-15 , DOI: 10.1021/acsapm.1c00496 Willian Max O. S. de Santana 1 , Sébastien Abramson 2 , Rodolfo Fini 1 , Bruno L. Caetano 1, 2, 3 , Christine Ménager 2 , Sandra H. Pulcinelli 1 , Celso V. Santilli 1
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In this work, we evaluate the effect of the ureasil–polyether hybrid nature on the magnetic hyperthermia (MH) properties and drug delivery patterns of nanocomposites prepared by the conjugation of cobalt ferrite (CoFe2O4) superparamagnetic nanoparticles (SPN) with ureasil–poly(propylene oxide) (UPPO) and ureasil–poly(ethylene oxide) (UPEO). The results of small-angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) analyses evidenced that the nanoscopic structure and thermal properties remained essentially unaffected by conjugation of the SPN with the hybrid material. The lower heat capacity of the UPPO–CoFe2O4 nanocomposite promoted a higher efficiency of MH compared to the UPEO–CoFe2O4 nanocomposite. The temperature variations achieved by UPPO–CoFe2O4 and UPEO–CoFe2O4 were 34 and 20 °C, respectively, when subjected to an alternating magnetic field (AMF) for 240 s. The drug delivery patterns of sodium diclofenac (SDCF) from UPPO and UPEO were unaffected by the conjugation with SPN or by MH.
中文翻译：
Ureasil–Polyether–CoFe2O4 纳米复合材料：耦合给药系统和磁热疗
在这项工作中，我们评估了尿素-聚醚杂化性质对铁氧体钴（CoFe 2 O 4）超顺磁性纳米颗粒（SPN）与尿素-聚（环氧丙烷）（UPPO）和脲基-聚（环氧乙烷）（UPEO）。小角 X 射线散射 (SAXS) 和差示扫描量热法 (DSC) 分析的结果证明，纳米结构和热性能基本上不受 SPN 与混合材料共轭的影响。所述UPPO-的CoFe的较低的热容量2 ö 4的纳米复合材料促进MH的更高的效率相比UPEO-的CoFe 2 ö4纳米复合材料。UPPO–CoFe 2 O 4和UPEO–CoFe 2 O 4在交变磁场(AMF) 作用240 秒时，温度变化分别为34 和20 °C。来自 UPPO 和 UPEO 的双氯芬酸钠 (SDCF) 的药物递送模式不受与 SPN 或 MH 结合的影响。
更新日期：2021-10-08
中文翻译：
Ureasil–Polyether–CoFe2O4 纳米复合材料：耦合给药系统和磁热疗
在这项工作中，我们评估了尿素-聚醚杂化性质对铁氧体钴（CoFe 2 O 4）超顺磁性纳米颗粒（SPN）与尿素-聚（环氧丙烷）（UPPO）和脲基-聚（环氧乙烷）（UPEO）。小角 X 射线散射 (SAXS) 和差示扫描量热法 (DSC) 分析的结果证明，纳米结构和热性能基本上不受 SPN 与混合材料共轭的影响。所述UPPO-的CoFe的较低的热容量2 ö 4的纳米复合材料促进MH的更高的效率相比UPEO-的CoFe 2 ö4纳米复合材料。UPPO–CoFe 2 O 4和UPEO–CoFe 2 O 4在交变磁场(AMF) 作用240 秒时，温度变化分别为34 和20 °C。来自 UPPO 和 UPEO 的双氯芬酸钠 (SDCF) 的药物递送模式不受与 SPN 或 MH 结合的影响。
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