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Fullerene-Based Mimics of Biocatalysts Show Remarkable Activity and Modularity
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-09-14 , DOI: 10.1021/acsami.1c11516 Gülcihan Gülseren 1, 2 , Aytül Saylam 1 , Antoine Marion 1 , Salih Özçubukçu 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-09-14 , DOI: 10.1021/acsami.1c11516 Gülcihan Gülseren 1, 2 , Aytül Saylam 1 , Antoine Marion 1 , Salih Özçubukçu 1
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The design of catalysts with greater control over catalytic activity and stability is a major challenge with substantial impact on fundamental chemistry and industrial applications. Due to their unparalleled diversity, selectivity, and efficiency, enzymes are promising models for next-generation catalysts, and considerable efforts have been devoted to incorporating the principles of their mechanisms of action into artificial systems. We report a heretofore undocumented catalyst design that introduces fullerenes to the field of biocatalysis, which we refer to as fullerene nanocatalysts, and that emulates enzymatic active sites through multifunctional self-assembled nanostructures. As a proof-of-concept, we mimicked the reactivity of hydrolases using fullerene nanocatalysts functionalized with the basic components of the parent enzyme with remarkable activity. Owing to the versatile amino acid-based functionalization repertoire of fullerene nanocatalysts, these next-generation carbon/biomolecule hybrids have potential to mimic the activity of other families of enzymes and, therefore, offer new perspectives for the design of biocompatible, high-efficiency artificial nanocatalysts.
中文翻译：
基于富勒烯的生物催化剂模拟物显示出显着的活性和模块化
设计能够更好地控制催化活性和稳定性的催化剂是一项重大挑战，对基础化学和工业应用具有重大影响。由于其无与伦比的多样性、选择性和效率，酶是下一代催化剂的有前途的模型，并且已经投入大量精力将其作用机制的原理纳入人工系统。我们报告了迄今为止未记录的催化剂设计，该设计将富勒烯引入生物催化领域，我们将其称为富勒烯纳米催化剂，并且通过多功能自组装纳米结构模拟酶活性位点。作为概念验证，我们使用富勒烯纳米催化剂模拟水解酶的反应性，该催化剂由具有显着活性的母体酶的基本成分功能化。由于富勒烯纳米催化剂具有多功能的基于氨基酸的功能化库，这些下一代碳/生物分子杂化物有可能模仿其他酶家族的活性，因此为设计生物相容性、高效人工纳米催化剂。
更新日期：2021-09-29
中文翻译：
基于富勒烯的生物催化剂模拟物显示出显着的活性和模块化
设计能够更好地控制催化活性和稳定性的催化剂是一项重大挑战，对基础化学和工业应用具有重大影响。由于其无与伦比的多样性、选择性和效率，酶是下一代催化剂的有前途的模型，并且已经投入大量精力将其作用机制的原理纳入人工系统。我们报告了迄今为止未记录的催化剂设计，该设计将富勒烯引入生物催化领域，我们将其称为富勒烯纳米催化剂，并且通过多功能自组装纳米结构模拟酶活性位点。作为概念验证，我们使用富勒烯纳米催化剂模拟水解酶的反应性，该催化剂由具有显着活性的母体酶的基本成分功能化。由于富勒烯纳米催化剂具有多功能的基于氨基酸的功能化库，这些下一代碳/生物分子杂化物有可能模仿其他酶家族的活性，因此为设计生物相容性、高效人工纳米催化剂。
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