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Phenibut, a GABAB Agonist, Detected in a Fatality
Journal of Analytical Toxicology ( IF 2.3 ) Pub Date : 2021-09-08 , DOI: 10.1093/jat/bkab099
Crystal Arndt 1 , Teresa R Gray 1
Affiliation  

Phenibut, a GABAB agonist structurally similar to baclofen, is not approved for medical use in the USA but is available through internet suppliers for recreational use. Calls to poison control centers for phenibut have increased over the last 5 years, and there are many case reports of severe acute intoxications and withdrawals requiring hospitalization. This case report describes the autopsy and toxicology findings of a 26-year-old male found dead at home with phenibut containers on the scene. Autopsy findings and routine toxicology testing were generally unremarkable. Scene findings prompted the validation of a qualitative liquid chromatography tandem mass spectrometry method that confirmed the presence of phenibut in blood and urine.

中文翻译:


Phenibut,一种 GABAB 激动剂,被发现导致死亡



Phenibut 是一种 GABAB 激动剂,结构与巴氯芬相似,在美国未获批准用于医疗用途,但可通过互联网供应商获得用于娱乐用途。过去 5 年来,向毒物控制中心求助的芬尼布特数量有所增加,并且有许多严重急性中毒和需要住院治疗的戒断病例报告。本病例报告描述了一名 26 岁男性死在家中的尸检和毒理学结果,现场有苯酚容器。尸检结果和常规毒理学测试通常没有什么异常。现场发现促使定性液相色谱串联质谱方法得到验证,证实血液和尿液中存在苯尼布。
更新日期:2021-09-08
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