Abstract

STUDY QUESTION

What is the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcome of a pregnancy after medically assisted reproduction (MAR)?

SUMMARY ANSWER

Our results suggest that MAR pregnancies are not differentially affected by SARS-CoV-2 infection compared to spontaneous pregnancies.

WHAT IS KNOWN ALREADY

Information on the effects of coronavirus disease 2019 (COVID-19) on pregnancy after MAR is scarce when women get infected during MAR or early pregnancy, even though such information is vital for informing women seeking pregnancy.

STUDY DESIGN, SIZE, DURATION

Data from SARS-CoV-2 affected MAR pregnancies were collected between May 2020 and June 2021 through a voluntary data collection, organised by the European Society of Human Reproduction and Embryology (ESHRE).

PARTICIPANTS/MATERIALS, SETTING, METHODS

All ESHRE members were invited to participate to an online data collection for SARS-CoV-2-infected MAR pregnancies.

MAIN RESULTS AND THE ROLE OF CHANCE

The dataset includes 80 cases from 32 countries, including 67 live births, 10 miscarriages, 2 stillbirths and 1 maternal death. An additional 25pregnancies were ongoing at the time of writing.

LIMITATIONS, REASONS FOR CAUTION

An international data registry based on voluntary contribution can be subject to selective reporting with possible risks of over- or under-estimation.

WIDER IMPLICATIONS OF THE FINDINGS

The current data can be used to guide clinical decisions in the care of women pregnant after MAR, in the context of the COVID-19 pandemic.

STUDY FUNDING/COMPETING INTEREST(S)

The authors acknowledge the support of ESHRE for the data registry and meetings. J.S.T. reports grants or contracts from Sigrid Juselius Foundation, EU and Helsinki University Hospital Funds, outside the scope of the current work. The other authors declare that they have no conflict of interest.

TRIAL REGISTRATION NUMBER

N/A.

中文翻译：

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医学辅助生殖后感染 SARS-CoV-2 的妊娠结果

摘要

研究问题

严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染对医学辅助生殖 (MAR) 后的妊娠结果有何影响？

总结答案

我们的研究结果表明，与自然妊娠相比，MAR 妊娠不受 SARS-CoV-2 感染的不同影响。

已知信息

当女性在 MAR 或早孕期间被感染时，关于 2019 年冠状病毒病 (COVID-19) 对 MAR 后妊娠的影响的信息很少，尽管此类信息对于告知寻求怀孕的女性至关重要。

研究设计、规模、持续时间

2020 年 5 月至 2021 年 6 月期间，通过由欧洲人类生殖与胚胎学学会 (ESHRE) 组织的自愿数据收集，收集了受 SARS-CoV-2 影响的 MAR 妊娠的数据。

参与者/材料、设置、方法

所有 ESHRE 成员都被邀请参加针对感染 SARS-CoV-2 的 MAR 怀孕的在线数据收集。

主要结果和机会的作用

该数据集包括来自 32 个国家的 80 例病例，其中包括 67 例活产、10 例流产、2 例死产和 1 例孕产妇死亡。在撰写本文时，还有 25 次怀孕正在进行中。

限制，谨慎的原因

基于自愿捐款的国际数据登记处可能会受到选择性报告的影响，可能存在高估或低估风险。

调查结果的更广泛影响

在 COVID-19 大流行的背景下，当前数据可用于指导 MAR 后孕妇护理的临床决策。

研究资金/竞争兴趣

作者感谢 ESHRE 对数据注册和会议的支持。JST 报告了当前工作范围之外的 Sigrid Juselius 基金会、欧盟和赫尔辛基大学医院基金的赠款或合同。其他作者声明他们没有利益冲突。

试用注册号

不适用。