To document the presentation of unilateral combined endophthalmitis and orbital cellulitis in patients with COVID-19 infection and study their prognosis. This interventional case series study included 9 patients referred to the Ophthalmology Department, Minia University Hospital with unilateral combined endophthalmitis and orbital cellulitis between April 2020 and March 2021. In addition to the COVID-19 work-up, all patients were subjected to full ophthalmological evaluation and managed according to their ophthalmic and systemic disease. The patients were 5 females and 4 males. They had clinical, laboratory and imaging findings that confirmed COVID-19 infection. All patients had unilateral endophthalmitis with orbital cellulitis and profound visual loss in the affected eye. Three patients died due to respiratory failure, while 6 patients recovered systemically. The survived patients developed atrophia bulbi in 4 patients and in 2 patients, the globe retained normal size but with complete visual loss. Combined endophthalmitis and orbital cellulitis can be one of the early presentations of patients with COVID-19 infection with poor visual prognosis. Clinical registration: clinicaltrials.gov identifier: NCT04456556 .

中文翻译：

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冠状病毒病（COVID-19）患者合并眼内炎和眼眶蜂窝织炎

记录 COVID-19 感染患者单侧眼内炎和眼眶蜂窝织炎的表现并研究其预后。这项介入性病例系列研究包括 2020 年 4 月至 2021 年 3 月期间转诊至米尼亚大学医院眼科的 9 名患有单侧眼内炎和眼眶蜂窝织炎的患者。除了 COVID-19 的检查外，所有患者都接受了全面的眼科评估并根据他们的眼科和全身疾病进行管理。患者为5女4男。他们的临床、实验室和影像学发现证实了 COVID-19 感染。所有患者均患有单侧眼内炎，伴眼眶蜂窝织炎，患眼严重视力丧失。三名患者因呼吸衰竭死亡，6例患者全身康复。幸存的患者中有 4 名出现了球茎萎缩，2 名患者的眼球保持正常大小，但视力完全丧失。合并眼内炎和眼眶蜂窝织炎可能是视力预后不良的 COVID-19 感染患者的早期表现之一。临床注册：clinicaltrials.gov 标识符：NCT04456556。