Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation.

中文翻译：

---

环状RNA的帽独立翻译蛋白及其在癌症中的作用


环状RNA是一类共价闭合RNA，在真核生物中广泛表达。 CircRNA参与多种生理和病理过程，但其调控机制尚不完全清楚。随着RNA深度测序技术的发展和算法的完善，一些CircRNA被发现通过帽无关机制编码蛋白质，参与肿瘤发生发展的重要过程。本文在对CircRNAs进行综述的基础上，总结了其翻译机制和研究方法，并综述了近年来CircRNAs翻译在肿瘤学领域的研究进展。此外，本文旨在通过CircRNA翻译为肿瘤诊断和治疗提供新思路。