The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD.

中文翻译：

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自闭症的肠道-微生物群-大脑轴：果蝇模型可以提供什么？


肠道-微生物-大脑轴（​​GUMBA）介导的沟通的改变在自闭症等人类大脑疾病中发挥着至关重要的作用，这一观点仍然是各个实验室深入研究的主题。胃肠道问题是自闭症谱系障碍 (ASD) 患者常见的合并症。尽管肠道微生物组和微生物代谢物与 ASD 的病因有关，但其潜在的分子机制仍然很大程度上未知。在这篇综述中，我们总结了人类和动物模型的最新发现，强调了肠脑轴在自闭症谱系障碍中的作用。我们讨论了果蝇作为动物模型的遗传和神经行为特征，以研究 GUMBA 在 ASD 中的作用。果蝇作为一种合适的遗传工具，结合无菌和无菌方法，以及转基因果蝇的可用性，可能揭示肠道-微生物群-大脑相互作用的机制洞察，以及其改变对与自闭症谱系障碍等神经系统疾病相关的行为的影响。