To study the RBCs functional and metabolic parameters and the microcirculatory brain structure at traumatic brain injury (TBI) under the action of 2-ethyl-6-methyl-3-hydroxypyridine succinate. A closed TBI was modeled by the free fall of a load on the parietooccipital regions of head. We made studies of the influence of 2-ethil-6-methil-3-hydroxipiridin succinate on aggregation and electrophoretic mobility of RBCs, catalase activity, malonic dialdehyde concentration, adenosine triphosphate and 2.3-biphosphoglycerate (2.3 – BPG) concentrations in RBCs. The state of parenchyma and microcirculatory brain mainstream in post-traumatic period of TBI have been studied on micro-preparations. The use of 2-ethyl-6-methyl-3-hydroxypyridine succinate under conditions of head injury leads to a decrease in MDA concentration and in aggregation of RBCs, to an increase in the 2.3—BPG concentration and RBC electrophoretic mobility compared to the control (group value). The most pronounced changes under the action of 2-ethyl-6-methyl-3-hydroxypyridine succinate were observed 3–7 days after the TBI. Significant indicators of the restoration of the microvasculature and brain tissue provoked by the use of 2-ethyl-6-methyl-3-hydroxypyridine succinate of were evident from the 7th day unlike the control group, where the restoration of structural morphological parameters was observed only on the 12th day of the post-traumatic period. Fast recovery of blood flow under the action of 2-ethyl-6-methyl-3-hydroxypyridine succinate ensured effective restoration of neurons and glia in comparison with the control group. Early and long-term cytoprotective correction intensifies the oxygen transport function of the blood, prevents and / or reduces disorders of microvessels, neurons and glia in the post-traumatic period, thereby provides correction of hypoxic state and drives to the restoration of brain tissues homeostasis.

中文翻译：

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2-ethil-6-methil-3-hydroxypiridin succinate作用对脑外伤红细胞及微循环功能指标的影响

研究2-乙基-6-甲基-3-羟基吡啶琥珀酸酯作用下创伤性脑损伤(TBI)红细胞功能代谢参数及脑微循环结构。闭合的 TBI 是通过负载在头部顶枕区域的自由落体来模拟的。我们研究了琥珀酸 2-ethil-6-methil-3-hydroxipiridin 对红细胞聚集和电泳迁移率、过氧化氢酶活性、丙二醛浓度、三磷酸腺苷和 2.3-二磷酸甘油酸 (2.3-BPG) 浓度的影响。微制剂研究了TBI创伤后脑实质和微循环脑主流的状态。在头部受伤的情况下使用 2-乙基-6-甲基-3-羟基吡啶琥珀酸盐导致 MDA 浓度降低和红细胞聚集，与对照组（组值）相比，2.3-BPG 浓度和 RBC 电泳迁移率增加。在 TBI 后 3-7 天观察到在 2-乙基-6-甲基-3-羟基吡啶琥珀酸盐的作用下最显着的变化。与仅观察到结构形态参数恢复的对照组不同，从第 7 天开始，使用 2-乙基-6-甲基-3-羟基吡啶琥珀酸盐引起的微血管和脑组织恢复的显着指标很明显在创伤后的第 12 天。与对照组相比，2-乙基-6-甲基-3-羟基吡啶琥珀酸酯作用下血流快速恢复，保证了神经元和胶质细胞的有效恢复。