Contemporary practice guidelines recommend using pooled cohort equations (PCEs)¹ to predict 10-year risk of atherosclerotic cardiovascular disease (ASCVD). In 2019, the American College of Cardiology (ACC) and the American Heart Association (AHA)² issued an updated primary prevention guideline for cardiovascular disease. To personalize patient-clinician discussions of ASCVD risk, the ACC/AHA guideline recognized premature menopause as a risk-enhancing factor among women younger than 40 years.² Conventional ASCVD risk calculations currently do not include premature menopause. Thus, the extent to which premature menopause may quantitatively change risk prediction of ASCVD, beyond traditional risk factors such as diabetes, hyperlipidemia, hypertension, and obesity, is unknown. This cohort study assessed whether adding premature menopause status to PCEs improves risk prediction of ASCVD among women.

当代实践指南推荐使用汇集队列方程 (PCE) ¹来预测动脉粥样硬化性心血管疾病 (ASCVD) 的 10 年风险。2019 年，美国心脏病学会 (ACC) 和美国心脏协会 (AHA) ²发布了更新的心血管疾病一级预防指南。为了个性化患者与临床医生对 ASCVD 风险的讨论，ACC/AHA 指南将过早绝经视为 40 岁以下女性的风险增加因素。²传统的 ASCVD 风险计算目前不包括过早绝经。因此，除了糖尿病、高脂血症、高血压和肥胖等传统风险因素之外，过早绝经可能在多大程度上改变 ASCVD 的风险预测是​​未知的。这项队列研究评估了在 PCE 中增加过早绝经状态是否可以提高女性 ASCVD 的风险预测。