Background. Coronavirus disease 2019 (COVID-19) manifestations varied completely from its time of emergence. However, the assessment of adrenal insufficiency (AI) in this pandemic is lacking. In this review, we aimed to evaluate the status of AI among COVID-19-infected individuals. Methods. A systematic literature screening in PubMed/MEDLINE, Scopus, and Web of Science was performed until May 23, 2021. We collected relevant published peer-reviewed studies that reported AI occurrence in patients who suffered from COVID-19. Results. A total of 10 records (cross-sectional studies: 3, N = 256, males: 176 (68.7%), and case reports: 7, N = 7, males: 4 (57.1%)) were recruited. The age spectrum ranged from 22 to 96 years. AI was diagnosed with laboratory assessment or radiologic findings. The AI prevalence ranged from 3.1% to as high as 64.3% in different studies. Except for one patient, all other patients were discharged in stable conditions in published case reports. Conclusion. This review indicates that AI occurrence in the COVID-19 pandemic seems quite probable; however, the extent and type (primary, secondary, and functional) need to be clarified yet. Appropriate early diagnostic and therapeutic interventions should be done, especially in critically ill patients, to prevent lethal outcomes.

中文翻译：

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2019 年冠状病毒病 (COVID-19) 感染且无肾上腺疾病的患者中的肾上腺功能不全：系统文献综述


背景。 2019 年冠状病毒病 (COVID-19) 的表现与其出现时完全不同。然而，目前尚缺乏对此次大流行中肾上腺功能不全（AI）的评估。在这篇综述中，我们的目的是评估 COVID-19 感染者的人工智能状况。方法。截至 2021 年 5 月 23 日，我们在 PubMed/MEDLINE、Scopus 和 Web of Science 中进行了系统的文献筛选。我们收集了相关已发表的同行评审研究，这些研究报告了 COVID-19 患者中发生 AI 的情况。结果。总共招募了 10 条记录（横断面研究：3 条， N = 256，男性：176 条（68.7%），病例报告：7 条， N = 7，男性：4 条（57.1%））。年龄范围从22岁到96岁。 AI 是通过实验室评估或放射学检查结果诊断的。在不同的研究中，AI 患病率从 3.1% 到高达 64.3% 不等。根据已发表的病例报告，除一名患者外，其他患者均已出院，病情稳定。结论。这篇评论表明，人工智能在 COVID-19 大流行中出现的可能性似乎很大；然而，其范围和类型（主要的、次要的和功能性的）还需要澄清。应采取适当的早期诊断和治疗干预措施，特别是对于危重患者，以防止致命的结果。