Background:

The Monocyte to high density lipoprotein ratio (MHR) has been postulated as a novel parameter associated with adverse renal and cardiovascular outcomes. In this study we investigated the association of MHR with cardiac surgery-associated acute kidney injury (CSA-AKI).

Methods:

In this retrospective study, we analyzed the data pertaining to 1505 patients undergoing cardiopulmonary bypass (CPB) surgery. The CSA-AKI, which was defined using Kidney Disease Improving Global Outcomes criteria. Concurrently, a retrospective scan of patient files was conducted and information relevant to nephropathy such as the level of their serum creatinine (SCr), Blood urea nitrogen (BUN), uric acid (UA), serum cystatin C (Cys-C), total cholesterol (TC), triglycerides (TG), glucose and MHR, ejection fraction, CPB duration time, and other indicators.

Results:

About 1505 patients were studied of whom 195 developed AKI. MHR was significantly higher in the AKI patients (p = 0.001). In multivariate logistic regression analysis, MHR, UA, Cys-C, age, glucose, and history of chronic kidney disease or hypertension were independently correlated with CSA-AKI.

Conclusions:

As a laboratory index, the elevated MHR is convenient, independent, and a useful predictor for CSA-AKI.

中文翻译：

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心脏手术后急性肾损伤患者单核细胞与高密度脂蛋白比值

背景：

单核细胞与高密度脂蛋白比率 (MHR) 已被假定为与不良肾脏和心血管结果相关的新参数。在这项研究中，我们调查了 MHR 与心脏手术相关急性肾损伤 (CSA-AKI) 的关联。

方法：

在这项回顾性研究中，我们分析了 1505 名接受体外循环 (CPB) 手术的患者的数据。CSA-AKI 是使用肾脏疾病改善全球结果标准定义的。同时，对患者档案进行了回顾性扫描，并获得了与肾病相关的信息，例如他们的血清肌酐 (SCr)、血尿素氮 (BUN)、尿酸 (UA)、血清胱抑素 C (Cys-C)、总胆固醇（TC）、甘油三酯（TG）、葡萄糖和MHR、射血分数、体外循环持续时间等指标。

结果：

研究了大约 1505 名患者，其中 195 名发生了 AKI。AKI 患者的 MHR 显着更高 (p = 0.001)。在多变量逻辑回归分析中，MHR、UA、Cys-C、年龄、血糖和慢性肾脏病或高血压病史与 CSA-AKI 独立相关。

结论：

作为一项实验室指标，升高的 MHR 是方便的、独立的，并且是 CSA-AKI 的有用预测指标。