Aerobic Direct Dioxygenation of Terminal/Internal Alkynes to α-Hydroxyketones by an Fe Porphyrin Catalyst,Chemistry - An Asian Journal

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Aerobic Direct Dioxygenation of Terminal/Internal Alkynes to α-Hydroxyketones by an Fe Porphyrin Catalyst
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2021-09-14 , DOI: 10.1002/asia.202101019
Kento Kimura ₁ , Takuya Kurahashi ₁ , Seijiro Matsubara ₁

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The synthesis of α-hydroxyketones through the dioxygenation of alkynes is reported. The reaction is mediated by an Fe porphyrin complex and pinacolborane at room temperature under air as a green oxidant, furnishing α-hydroxyketones in up to 93% yields. The mild reaction conditions allow chemoselective oxidation with good functional group tolerance.