Chemoenzymatic Asymmetric Synthesis of Pyridine-Based α-Fluorinated Secondary Alcohols,ChemBioChem

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Chemoenzymatic Asymmetric Synthesis of Pyridine-Based α-Fluorinated Secondary Alcohols
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-14 , DOI: 10.1002/cbic.202100392
Timo Broese _{1,

2} , Peter Ehlers ₃ , Peter Langer ₃ , Jan von Langermann ₁

Affiliation

Two for one: A straightforward chemoenzymatic synthesis pathway towards valuable chiral alcohols with α-fluorination in close proximity to the chiral center and a pyridine ring is presented. High conversions with excellent enantioselectivities were found, showing its high synthetic potential.