Asymmetric Stepwise Reductive Amination of Aryl N-Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis,Asian Journal of Organic Chemistry

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Asymmetric Stepwise Reductive Amination of Aryl N-Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-09-15 , DOI: 10.1002/ajoc.202100472
Bing Yang ₁ , Hao Fu ₂ , Jing Yuan ₃ , Simiaomiao Wen ₂ , Chunqin Wang ₄ , Qixing Liu ₂ , Haifeng Zhou ₅

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Various chiral aryl N-heteroaryl methylamines were prepared with good yields and up to 99% enantioselectivity via one-pot stepwise ketimine formation/asymmetric transfer hydrogenation of aryl N-heteroaryl ketones and benzyl amines.