3D Printing of Black Bioceramic Scaffolds with Micro/Nanostructure for Bone Tumor-Induced Tissue Therapy,Advanced Healthcare Materials

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3D Printing of Black Bioceramic Scaffolds with Micro/Nanostructure for Bone Tumor-Induced Tissue Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-09-15 , DOI: 10.1002/adhm.202101181
Xin Wang _{1,

2} , Yin Liu ₁ , Meng Zhang _{1,

2} , Dong Zhai _{1,

2} , Yufeng Wang _{1,

3} , Hui Zhuang _{1,

2} , Bing Ma _{1,

2} , Yu Qu _{1,

2} , Xiaopeng Yu _{1,

2} , Jingge Ma _{1,

2} , Hongshi Ma _{1,

2} , Qingqiang Yao ₃ , Chengtie Wu _{1,

2}

Affiliation

It is common to improve the relevant performance in the field of energy storage materials or catalytic materials by regulating the number of defects. However, there are few studies on the biomaterials containing defects for tissue engineering. Herein, a new type of defect-rich scaffolds, black akermanite (B-AKT) bioceramic scaffolds with micro/nanostructure, the thickness of which is from 0.14 to 1.94 µm, is fabricated through introducing defects on the surface of bioceramic scaffolds. The B-AKT scaffolds have advantages on the degradation rate and the osteogenic capacity over the AKT (Ca₂MgSi₂O₇) scaffolds due to the surface defects which stimulate the osteogenic differentiation of rabbit bone mesenchymal stem cells via activating bone morphogenetic protein 2 （BMP2） signaling pathway and further promote bone formation in vivo. In addition, the prepared B-AKT scaffolds, the temperature of which can be over 100 °C under the near infrared （NIR） irradiation (0.66 W cm⁻²), possess excellent performance on photothermal and antitumor effects. The work develops an introducing-defect strategy for regulating the biological performance of bioceramic scaffolds, which is expected to be applied in the next generation of bioceramic scaffolds for regenerative medicine.

中文翻译：

用于骨肿瘤诱导组织治疗的具有微/纳米结构的黑色生物陶瓷支架的 3D 打印

通过调节缺陷数量来提高储能材料或催化材料领域的相关性能是很常见的。然而，对于含有缺陷的生物材料用于组织工程的研究很少。在此，通过在生物陶瓷支架表面引入缺陷，制备了一种新型的富含缺陷的支架，具有微/纳米结构的黑色镁铝石（B-AKT）生物陶瓷支架，其厚度为 0.14 至 1.94 µm。B-AKT 支架在降解率和成骨能力方面优于 AKT (Ca ₂ MgSi ₂ O ₇)支架由于表面缺陷，通过激活骨形态发生蛋白2（BMP2）信号通路刺激兔骨间充质干细胞的成骨分化，进一步促进体内骨形成。此外，所制备的B-AKT支架在近红外（NIR）照射（0.66 W cm ^-2）下温度可达100°C以上，具有优异的光热和抗肿瘤作用。该工作开发了一种用于调节生物陶瓷支架生物学性能的引入缺陷策略，有望应用于下一代再生医学生物陶瓷支架。

更新日期：2021-11-04

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