Objective

To evaluate whether the change in endometrial thickness from progesterone administration day to transfer day is related to pregnancy outcomes in single frozen-thawed euploid blastocyst transfer cycles.

Design

Observational cohort study.

Setting

Single reproductive medical center.

Patient(s)

All patients were transferred with a single biopsied euploid blastocyst, and their endometrium was prepared with hormone replacement therapy (HRT).

Intervention(s)

The endometrial thickness on the day of blastocyst transfer and progesterone administration was measured by transvaginal ultrasound, and the difference between them and the change ratio were calculated.

Main Outcome Measure(s)

Clinical pregnancy rates and live birth rates.

Result(s)

Endometrial ultrasound images of 508 euploid blastocyst transfer cycles using HRT were evaluated by transvaginal ultrasound. Overall, pregnancy outcomes were comparable in different groups of endometrial thickness changes. The results of multiple logistic regression showed that the clinical pregnancy rate and live birth rate did not significantly increase with the increase in endometrial thickness change ratios (per 10%) in the fully adjusted model as a continuous variable. In the adjustment model as a categorical variable, there was no statistical difference in pregnancy outcomes among the groups with changes in endometrial thickness. Interaction analysis showed that after adjusting for confounders, there was no statistically significant interaction between the endometrial thickness change ratio and pregnancy outcomes in all subgroups.

Conclusion(s)

In the euploid blastocyst transfer cycle of preparing the endometrium with HRT, the endometrial thickness change ratio after progesterone administration was not related to pregnancy outcomes.

中文翻译：

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服用黄体酮后子宫内膜厚度变化不影响冻融整倍体囊胚移植的妊娠结局：一项回顾性队列研究

客观的

评估从孕酮给药日到移植日子宫内膜厚度的变化是否与单次冻融整倍体囊胚移植周期的妊娠结局有关。

设计

观察性队列研究。

环境

单一生殖医学中心。

耐心）

所有患者均移植单次活检整倍体囊胚，并用激素替代疗法（HRT）制备子宫内膜。

干预措施

经阴道超声测量囊胚移植和黄体酮给药当天的子宫内膜厚度，并计算其差值和变化率。

主要观察指标）

临床妊娠率和活产率。

结果）

通过经阴道超声评估使用 HRT 的 508 个整倍体囊胚移植周期的子宫内膜超声图像。总体而言，不同子宫内膜厚度变化组的妊娠结局具有可比性。多元logistic回归结果显示，在完全调整后的模型中，以子宫内膜厚度变化率（每10%）的增加为连续变量，临床妊娠率和活产率并未显着增加。在作为分类变量的调整模型中，子宫内膜厚度变化的组间妊娠结局无统计学差异。交互作用分析显示，在调整混杂因素后，所有亚组的子宫内膜厚度变化率与妊娠结局之间均无统计学意义的交互作用。

结论

在HRT准备子宫内膜的整倍体囊胚移植周期中，服用黄体酮后子宫内膜厚度变化率与妊娠结局无关。