Frontiers in Bioengineering and Biotechnology ( IF 4.3 ) Pub Date : 2021-09-15 , DOI: 10.3389/fbioe.2021.711787 Feng Wang 1 , Lei Dong 1 , Xixi Wei 2 , Yongling Wang 2 , Liansheng Chang 3 , Hongwei Wu 4 , Shuyuan Liu 5 , Yuqiao Chang 1 , Yaling Yin 2 , Xiaoqiu Luo 2 , Xiaojian Jia 6 , Fei Yan 7 , Nana Li 1
Gambogic acid (GA) is a highly effective antitumor agent, and it is used for the treatment of a wide range of cancers. It is challenging to deliver drugs to the central nervous system due to the inability of GA to cross the blood–brain barrier (BBB). Studies have shown that ultrasound-targeted microbubble destruction can be used for transient and reversible BBB disruption, significantly facilitating intracerebral drug delivery. We first prepared GA–loaded porous-lipid microbubbles (GA porous-lipid/PLGA MBs), and an
中文翻译:
藤黄酸负载多孔脂质/PLGA微泡联合超声触发微泡破坏对人脑胶质瘤的影响
藤黄酸 (GA) 是一种高效的抗肿瘤剂,可用于治疗多种癌症。由于 GA 无法穿过血脑屏障 (BBB),因此将药物输送到中枢神经系统具有挑战性。研究表明,超声靶向微泡破坏可用于瞬时和可逆的 BBB 破坏,显着促进脑内给药。我们首先制备了负载 GA 的多孔脂质微泡(GA 多孔脂质 / PLGA MBs),并