The emergence of phytosome nanotechnology has a potential impact in the field of drug delivery and could revolutionize the current state of topical bioactive phytochemicals delivery. The main challenge facing the translation of the therapeutic activity of phytochemicals to a clinical setting is the extremely low absorption rate and poor penetration across biological barriers (i.e., the skin). Phytosomes as lipid-based nanocarriers play a crucial function in the enhancement of pharmacokinetic and pharmacodynamic properties of herbal-originated polyphenolic compounds, and make this nanotechnology a promising tool for the development of new topical formulations. The implementation of this nanosized delivery system could enhance the penetration of phytochemicals across biological barriers due to their unique physiochemical characteristics, improving their bioavailability. In this review, we provide an outlook on the current knowledge of the biological barriers of phytoconstituents topical applications. The great potential of the emerging nanotechnology in the delivery of bioactive phytochemicals is reviewed, with particular focus on phytosomes as an innovative lipid-based nanocarrier. Additionally, we compared phytosomes with liposomes as the gold standard of lipid-based nanocarriers for the topical delivery of phytochemicals. Finally, the advantages of phytosomes in topical applications are discussed.

中文翻译：

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Phytosomes 作为用于局部递送生物活性植物化学物质的新兴纳米技术平台

植物体纳米技术的出现对药物递送领域具有潜在影响，并可能彻底改变局部生物活性植物化学物质递送的现状。将植物化学物质的治疗活性转化为临床环境所面临的主要挑战是极低的吸收率和对生物屏障（即皮肤）的渗透性差。植物体作为基于脂质的纳米载体在增强草本多酚化合物的药代动力学和药效学特性方面起着至关重要的作用，并使这种纳米技术成为开发新局部制剂的有前途的工具。由于其独特的物理化学特性，这种纳米级递送系统的实施可以增强植物化学物质跨生物屏障的渗透，提高它们的生物利用度。在这篇综述中，我们对植物成分局部应用的生物屏障的当前知识进行了展望。综述了新兴纳米技术在递送生物活性植物化学物质方面的巨大潜力，特别关注植物体作为一种创新的基于脂质的纳米载体。此外，我们将植物体与脂质体作为用于局部递送植物化学物质的基于脂质的纳米载体的黄金标准进行了比较。最后，讨论了植物体在局部应用中的优势。特别关注植物体作为创新的基于脂质的纳米载体。此外，我们将植物体与脂质体作为用于局部递送植物化学物质的基于脂质的纳米载体的黄金标准进行了比较。最后，讨论了植物体在局部应用中的优势。特别关注植物体作为创新的基于脂质的纳米载体。此外，我们将植物体与脂质体作为用于局部递送植物化学物质的基于脂质的纳米载体的黄金标准进行了比较。最后，讨论了植物体在局部应用中的优势。