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Hemocompatible MOF-decorated pollen hemoperfusion absorbents for rapid and highly efficient removal of protein-bound uremic toxins
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2021-08-30 , DOI: 10.1039/d1qm01071a
Zhenhua Chao 1 , Jingyu Li 1 , Wenning Jiang 1 , Chong Zhang 1 , Jiaxin Ji 1 , Xia Hua 1 , Li Xu 1 , Lulu Han 1 , Lingyun Jia 1
Affiliation  

The accumulation of protein-bound uremic toxins (PBUTs) in the blood may result in the development of uremia into advanced stages. However, traditional hemoperfusion absorbents for PBUT removal have the main drawbacks of non-specific adhesion of plasma proteins, lower PBUT adsorption efficiency and poor hemocompatibility. Here, we report a micro–nanostructural design to synthesize a novel hemocompatible hemoperfusion absorbent by combining nanoporous hollow microspheres and PBUT-absorbing nanoparticles. Natural pollen nanoporous hollow microspheres were used as a skeleton to accelerate PBUT adsorption, and the PBUT-absorbing NU-1000 nanoparticles were in situ grown and decorated on the pollen skeleton (PPNU) via the intermediation of a polydopamine layer. Moreover, heparin was modified on the PPNU (PPNUH) to offer excellent hemocompatibility without sacrificing the PBUT-adsorbing sites of NU-1000. PPNUH specifically adsorbed PBUTs and possessed a high maximum adsorption capacity for various PBUTs (282 mg g−1 for p-cresyl sulfate, 329 mg g−1 for indoxyl sulfate, and 188 mg g−1 for quinoline acid). Furthermore, the integration of nanoporous hollow microspheres and PBUT-absorbing nanoparticles permitted quick adsorption of 85% of the free PBUT within 10 s while removing 70% of albumin-bound PBUTs within the first 1 min in simulated hemoperfusion. The exquisite micro–nanostructure of PPNUH and heparin modification synergistically achieved the efficient, rapid, and safe removal of PUBTs, and the design strategy provided a guiding idea for the development of future multifunctional and portable hemoperfusion materials.

中文翻译:

血液相容性 MOF 修饰的花粉血液灌注吸收剂,可快速高效去除蛋白质结合的尿毒症毒素

血液中蛋白质结合尿毒症毒素 (PBUT) 的积累可能导致尿毒症发展为晚期。然而,传统的用于去除 PBUT 的血液灌注吸收剂具有血浆蛋白非特异性粘附、PBUT 吸附效率低和血液相容性差等主要缺点。在这里,我们报告了一种微纳米结构设计,通过结合纳米多孔空心微球和 PBUT 吸收纳米颗粒来合成一种新型的血液相容性血液灌注吸收剂。以天然花粉纳米多孔空心微球为骨架加速PBUT吸附,吸附PBUT的NU-1000纳米颗粒原位生长并修饰在花粉骨架(PPNU)上。聚多巴胺层的中介。此外,肝素在 PPNU (PPNUH) 上进行了修饰,以在不牺牲 NU-1000 的 PBUT 吸附位点的情况下提供出色的血液相容性。PPNUH 特异性吸附 PBUT,对各种 PBUT 具有很高的最大吸附容量(甲酚硫酸酯282 mg g -1,硫酸吲哚酚329 mg g -1和 188 mg g -1喹啉酸)。此外,纳米多孔空心微球和吸收 PBUT 的纳米颗粒的整合允许在 10 秒内快速吸附 85% 的游离 PBUT,同时在模拟血液灌注的前 1 分钟内去除 70% 的白蛋白结合 PBUT。PPNUH精巧的微纳米结构与肝素修饰协同实现了PUBTs的高效、快速、安全去除,该设计策略为未来多功能便携式血液灌流材料的开发提供了指导思路。
更新日期:2021-09-15
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