Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers,Journal of the American Chemical Society

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Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2021-09-14 , DOI: 10.1021/jacs.1c05750
Wen-Zhi Wang ₁ , Li-Bo Huang ₂ , Shao-Ping Zheng ₂ , Emilie Moulin ₁ , Odile Gavat ₁ , Mihail Barboiu ₂ , Nicolas Giuseppone ₁

Affiliation

A hydrophobic light-driven rotary motor is functionalized with two 18-crown-6 macrocycles and incorporated into phospholipid bilayers. In the presence of this molecular construct, fluorescence assays and patch clamp experiments show the formation of selective alkali ion channels through the membrane. Further, they reveal a strongly accelerated ion transport mechanism under light irradiation. This increase of the fractional ion transport activity (up to 400%) is attributed to the out-of-equilibrium actuation dynamics of the light-driven rotary motors, which help to overcome the activation energy necessary to achieve translocation of alkali ions between macrocycles along the artificial channels.

中文翻译：

光驱动分子马达促进碱金属离子通过磷脂双层的选择性传输

疏水光驱动旋转电机具有两个 18-crown-6 大环功能化，并结合到磷脂双层中。在这种分子构建体存在的情况下，荧光分析和膜片钳实验表明通过膜形成了选择性碱离子通道。此外，它们揭示了在光照射下强烈加速的离子传输机制。分数离子传输活性的增加（高达 400%）归因于光驱动旋转电机的失衡驱动动力学，这有助于克服实现大环之间碱离子转移所需的活化能。人工渠道。

更新日期：2021-09-29

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