Rheumatoid arthritis (RA) patients have almost twice the risk of heart failure (HF) as individuals without RA, even with adjustment for the presence of ischemic heart disease. Moreover, RA patients remain at a 2-fold higher risk of mortality from HF compared to non–RA patients. These observations suggest that RA-specific inflammatory pathways are significant contributors to this increased risk of HF. Herein we summarize the epidemiology of HF in RA patients, the differences in myocardial structure or function between RA patients and non–RA patients without clinical signs of HF, and data on the role of systemic and local inflammation in RA HF pathophysiology. We also discuss the impact of subduing inflammation through the use of RA disease-modifying therapies on HF and myocardial structure and function, emphasizing gaps in the literature and areas needing further research.

中文翻译：

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类风湿性关节炎的心肌功能障碍和心力衰竭

类风湿性关节炎 (RA) 患者发生心力衰竭 (HF) 的风险几乎是没有 RA 的个体的两倍，即使对缺血性心脏病的存在进行了调整。此外，与非 RA 患者相比，RA 患者死于 HF 的风险仍然高出 2 倍。这些观察结果表明，RA 特异性炎症通路是导致 HF 风险增加的重要因素。在此，我们总结了 RA 患者 HF 的流行病学、RA 患者和无 HF 临床症状的非 RA 患者之间心肌结构或功能的差异，以及全身和局部炎症在 RA HF 病理生理学中作用的数据。我们还讨论了通过使用 RA 疾病修饰疗法来抑制炎症对 HF 和心肌结构和功能的影响，