Cellular prion protein (PrP^C), the primary form of prion diseases pathogen, has received increasing attention for its protective effect against ischaemic stroke. Little is known about its role in peripheral immune responses after cerebral ischaemia/reperfusion (I/R) injury. This study is to detect the variation of splenic CD4⁺ T lymphocytes differentiation and the concentration of inflammatory cytokines after murine cerebral I/R injury in the context of PRNP expression as well as its influence on the ischaemic neuronal apoptosis.

中文翻译：

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细胞朊病毒蛋白在脑缺血/再灌注脾CD4+T细胞分化中的作用

细胞朊病毒蛋白（PrP ^C）是朊病毒疾病病原体的主要形式，因其对缺血性中风的保护作用而受到越来越多的关注。关于它在脑缺血/再灌注 (I/R) 损伤后外周免疫反应中的作用知之甚少。本研究旨在检测PRNP表达背景下小鼠脑I/R损伤后脾脏CD4 ⁺ T淋巴细胞分化和炎性细胞因子浓度的变化及其对缺血性神经元凋亡的影响。