Physical and Bioactive Properties of Glycosaminoglycan Hydrogels Modulated by Polymer Design Parameters and Polymer Ratio,Biomacromolecules

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Physical and Bioactive Properties of Glycosaminoglycan Hydrogels Modulated by Polymer Design Parameters and Polymer Ratio
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-09-14 , DOI: 10.1021/acs.biomac.1c00866
Michael Nguyen ₁ , Julie C Liu _{2,

3} , Alyssa Panitch _{1,

4}

Affiliation

Glycosaminoglycans (GAGs), such as hyaluronic acid (HA) and chondroitin sulfate (CS), have seen widespread adoption as components of tissue engineering scaffolds because of their potent bioactive properties and ease of chemical modification. However, modification of the biopolymers will impair biological recognition of the GAG and reduce the bioactive properties of the material. In this work, we studied how the degree of thiolation of HA and CS, along with other key hydrogel design parameters, affected the physical and bioactive properties of the bulk hydrogel. Although properties, such as the HA molecular weight, did not have a major effect, increasing the degree of thiolation of both HA and CS decreased their biorecognition in experimental analogues for cell/matrix remodeling and binding. Furthermore, combining HA and CS into dual polymer network hydrogels also modulated the physical and bioactive properties, as seen with differences in gel stiffness, degradation rate, and encapsulated cell viability.

中文翻译：

聚合物设计参数和聚合物比例调节糖胺聚糖水凝胶的物理和生物活性特性

糖胺聚糖 (GAG)，例如透明质酸 (HA) 和硫酸软骨素 (CS)，由于其强大的生物活性和易于化学修饰而被广泛用作组织工程支架的成分。然而，生物聚合物的改性会损害 GAG 的生物识别并降低材料的生物活性。在这项工作中，我们研究了 HA 和 CS 的硫醇化程度以及其他关键水凝胶设计参数如何影响本体水凝胶的物理和生物活性特性。尽管 HA 分子量等特性没有产生重大影响，但增加 HA 和 CS 的硫醇化程度会降低它们在细胞/基质重塑和结合的实验类似物中的生物识别能力。此外，将 HA 和 CS 组合成双聚合物网络水凝胶还可以调节物理和生物活性特性，如凝胶硬度、降解率和封装细胞活力的差异所示。

更新日期：2021-10-12

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