Adiponectin is an adipocyte-derived hormone, which is closely associated with the development of Alzheimer's disease (AD) and has potential preventive and therapeutic significance. In the present study, we explored the relationship between adiponectin and circadian rhythm disorder in AD, the effect of adiponectin on the abnormal expression of Bmal1 mRNA/protein induced by amyloid-β protein 31-35 (Aβ31-35), and the underlying mechanism of action. We found that adiponectin-knockout mice exhibited amyloid-β deposition, circadian rhythm disorders and abnormal expression of Bmal1. Adiponectin ameliorated the abnormal expression of the Bmal1 mRNA/protein caused by Aβ31-35 by inhibiting the activity of glycogen synthase kinase 3β (GSK3β). These results suggest that adiponectin deficiency could induce circadian rhythm disorders and abnormal expression of the Bmal1 mRNA/protein, whilst exogenous administration of adiponectin may improve Aβ31-35-induced abnormal expression of Bmal1 by inhibiting the activity of GSK3β, thus providing a novel idea for the treatment of AD.

中文翻译：

---

脂联素可改善淀粉样蛋白-β 31-35 诱导的小鼠昼夜节律紊乱

脂联素是一种脂肪细胞衍生的激素，与阿尔茨海默病（AD）的发生发展密切相关，具有潜在的预防和治疗意义。在本研究中，我们探讨了脂联素与 AD 昼夜节律紊乱的关系，脂联素对β淀粉样蛋白 31-35 (Aβ31-35) 诱导的 Bmal1 mRNA/蛋白异常表达的影响及其潜在机制。的行动。我们发现脂联素敲除小鼠表现出β淀粉样蛋白沉积、昼夜节律紊乱和Bmal1异常表达。脂联素通过抑制糖原合酶激酶 3β (GSK3β) 的活性来改善由 Aβ31-35 引起的 Bmal1 mRNA/蛋白的异常表达。