Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseases including metabolic disorders. However, the regulatory pathways and molecules are not completely understood. The discovery of relevant responsible molecules and the associated network could be an attractive strategy to overcome diseases associated with muscle problems.

中文翻译：

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骨骼肌中 USP21 的消融促进氧化纤维表型，抑制肥胖和 2 型糖尿病

作为代谢消耗者的骨骼肌通过调节肌纤维类型转换和肌肉质量控制来决定全身能量稳态。骨骼肌代谢的扰动会增加各种疾病的风险，包括代谢紊乱。然而，调控途径和分子尚不完全清楚。相关负责分子和相关网络的发现可能是克服与肌肉问题相关的疾病的有吸引力的策略。