当前位置: X-MOL 学术J. Chem. Technol. Biotechnol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Perspectives on adsorption technology as an effective strategy for continuous downstream bioprocessing
Journal of Chemical Technology and Biotechnology ( IF 2.8 ) Pub Date : 2021-09-15 , DOI: 10.1002/jctb.6923
Anna Schneider 1 , Lisa‐Marie Herlevi 1 , Yijia Guo 1 , Marcelo Fernandez Lahore 1
Affiliation  

The biological industry, but also biorefining platforms in the context of the circular economy, have been fertile terrains for the development of a palette of novel products of increasing structural diversity and fields of application. To mention only a few of the more complex bioproducts, we can consider monoclonal antibodies, plasmid DNA, virus-like particles and exosomes. Of course, some products of industrial relevance are much simpler in nature. Irrespective of the product class and field of application, a shift from batch processing to continuous manufacturing is currently happening. This is due to the fact that operating in the continuous mode can result in process intensification, and therefore increased productivity with lower environmental impact can be realized. Some biological production schemes, e.g. those based on perfusion cultures, are well known in the pharmaceutical industry. Likewise, continuous fermentation is now utilized to produce ethanol from biomass. In many cases, continuous downstream operations are desired but difficult to implement; there is a pressing need to better understand the available options for product recovery and purification. Some traditional methods require re-evaluation in modern contexts and some others, of experimental nature, require further improvement before actual implementation. In this article, we present an overview of the most promising methods that would allow for robust downstream bioprocessing options in the near future – with a focus on adsorption technologies. © 2021 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).

中文翻译:

吸附技术作为连续下游生物加工的有效策略的观点

生物工业,以及循环经济背景下的生物精炼平台,一直是开发一系列结构多样性和应用领域不断增加的新产品的沃土。仅提及一些更复杂的生物产品,我们可以考虑单克隆抗体、质粒 DNA、病毒样颗粒和外泌体。当然,一些与工业相关的产品本质上要简单得多。无论产品类别和应用领域如何,目前都在发生从批处理向连续制造的转变。这是因为在连续模式下操作会导致工艺强化,因此可以实现更高的生产率和更低的环境影响。一些生物生产方案,例如那些基于灌注培养的方案,在制药行业享有盛誉。同样,现在利用连续发酵从生物质中生产乙醇。在许多情况下,需要连续的下游操作,但难以实施;迫切需要更好地了解产品回收和纯化的可用选项。一些传统方法需要在现代环境中重新评估,而其他一些具有实验性质的方法需要在实际实施之前进一步改进。在本文中,我们概述了最有前途的方法,这些方法将在不久的将来实现稳健的下游生物加工选择——重点是吸附技术。© 2021 作者。需要连续的下游操作,但难以实施;迫切需要更好地了解产品回收和纯化的可用选项。一些传统方法需要在现代环境中重新评估,而其他一些具有实验性质的方法需要在实际实施之前进一步改进。在本文中,我们概述了最有前途的方法,这些方法将在不久的将来实现稳健的下游生物加工选择——重点是吸附技术。© 2021 作者。需要连续的下游操作,但难以实施;迫切需要更好地了解产品回收和纯化的可用选项。一些传统方法需要在现代环境中重新评估,而其他一些具有实验性质的方法需要在实际实施之前进一步改进。在本文中,我们概述了最有前途的方法,这些方法将在不久的将来实现稳健的下游生物加工选择——重点是吸附技术。© 2021 作者。在实际实施之前需要进一步改进。在本文中,我们概述了最有前途的方法,这些方法将在不久的将来实现稳健的下游生物加工选择——重点是吸附技术。© 2021 作者。在实际实施之前需要进一步改进。在本文中,我们概述了最有前途的方法,这些方法将在不久的将来实现稳健的下游生物加工选择——重点是吸附技术。© 2021 作者。John Wiley & Sons Ltd 代表化学工业协会 (SCI) 出版的《化学技术和生物技术杂志》。
更新日期:2021-09-15
down
wechat
bug