Viruses are known to cause various diseases in human and also infect other species such as animal plants, fungi, and bacteria. Replication of viruses depends upon their interaction with hosts. Human cells are prone to such unwanted viral infections. Disintegration and reconstitution require host machinery and various macromolecules like DNA, RNA, and proteins are invaded by viral particles. E3 ubiquitin ligases are known for their specific function, that is, recognition of their respective substrates for intracellular degradation. Still, we do not understand how ubiquitin proteasome system-based enzymes E3 ubiquitin ligases do their functional interaction with different viruses. Whether E3 ubiquitin ligases help in the elimination of viral components or viruses utilize their molecular capabilities in their intracellular propagation is not clear. The first time our current article comprehends fundamental concepts and new insights on the different viruses and their interaction with various E3 Ubiquitin Ligases. In this review, we highlight the molecular pathomechanism of viruses linked with E3 Ubiquitin Ligases dependent mechanisms. An enhanced understanding of E3 Ubiquitin Ligase-mediated removal of viral proteins may open new therapeutic strategies against viral infections.

中文翻译：

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E3泛素连接酶的生化策略靶向危重疾病中的病毒

已知病毒会在人类中引起各种疾病，并且还会感染其他物种，例如动植物、真菌和细菌。病毒的复制取决于它们与宿主的相互作用。人体细胞容易受到这种不需要的病毒感染。分解和重组需要宿主机器，并且各种大分子（如 DNA、RNA 和蛋白质）被病毒颗粒侵入。E3 泛素连接酶以其特定功能而闻名，即识别它们各自的底物以进行细胞内降解。尽管如此，我们仍不了解基于泛素蛋白酶体系统的酶 E3 泛素连接酶如何与不同病毒进行功能性相互作用。E3 泛素连接酶是否有助于消除病毒成分或病毒在细胞内传播中利用其分子能力尚不清楚。我们目前的文章第一次理解了关于不同病毒及其与各种 E3 泛素连接酶相互作用的基本概念和新见解。在这篇综述中，我们强调了与 E3 泛素连接酶依赖机制相关的病毒的分子病理机制。对 E3 泛素连接酶介导的病毒蛋白去除的深入了解可能会开辟针对病毒感染的新治疗策略。