Multiscale conformational dynamics probed by time-resolved circular dichroism from seconds to picoseconds,Chirality

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Multiscale conformational dynamics probed by time-resolved circular dichroism from seconds to picoseconds
Chirality ( IF 2.8 ) Pub Date : 2021-09-14 , DOI: 10.1002/chir.23359
François Hache ₁ , Pascale Changenet ₁

Affiliation

Time-resolved circular dichroism has been developed for a few decades to investigate rapid conformational changes in (bio)molecules. In our group, we have come up with several experimental set-ups allowing us to study pico-nanosecond local phenomena in molecular systems as well as much slower effects occurring in proteins and DNA in the folding processes. After an overview of the worldwide realizations in this domain, we present emblematic experiments that we have carried out, spanning time domain from picoseconds to seconds.

中文翻译：

通过从秒到皮秒的时间分辨圆二色性探测多尺度构象动力学

时间分辨圆二色性已经发展了几十年，以研究（生物）分子的快速构象变化。在我们的小组中，我们提出了几个实验装置，使我们能够研究分子系统中的皮纳秒局部现象以及折叠过程中蛋白质和 DNA 中发生的慢得多的效应。在概述了该领域的全球实现之后，我们展示了我们进行的标志性实验，跨越从皮秒到秒的时域。

更新日期：2021-10-12

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