Advances in non-palladium-catalysed Stille couplings,Applied Organometallic Chemistry

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Advances in non-palladium-catalysed Stille couplings
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2021-09-14 , DOI: 10.1002/aoc.6430
Mary Baby Aleena ₁ , Rose Mary Philip ₁ , Gopinathan Anilkumar _{1,

2,

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Affiliation

Stille coupling is regarded as a powerful tool in the synthesis of a wide range of functionalised C–C bonds due to the high stability, availability and broad functional group compatibility of the organostannanes. This is the first review solely focused on the role of the non-palladium transition metals in Stille coupling with emphasis on their catalytic capacity and mechanistic details. Several transition metals including Mn, Ni, Cu, Rh, Pt, and Au are found highly efficient in the coupling with Cu having the largest reports. Importantly, Cu-catalysed Stille couplings formed the key stages in the synthesis of therapeutic molecules like 4(S)-11-diHDHA and Spliceostatin derivatives.

中文翻译：

非钯催化Stille偶合的进展

由于有机锡烷的高稳定性、可用性和广泛的官能团兼容性，Stille 偶联被认为是合成各种功能化 C-C 键的有力工具。这是第一次仅关注非钯过渡金属在 Stille 偶联中的作用，重点是它们的催化能力和机械细节。发现包括 Mn、Ni、Cu、Rh、Pt 和 Au 在内的几种过渡金属在与 Cu 的偶联中非常有效，报告最多。重要的是，Cu 催化的 Stille 偶联形成了治疗性分子（如 4( S )-11-diHDHA 和 Spliceostatin 衍生物）合成的关键阶段。

更新日期：2021-09-14

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