Gastric antral vascular ectasia (GAVE) is an uncommon clinical entity leading to recurrent gastrointestinal bleeding. There is no consensus regarding treatment of GAVE. Endoscopic therapy is the preferred treatment option, but has a fairly high recurrence rate. Surgical resection can completely resolve GAVE, but is invasive with a relatively high risk of postoperative complications. Recently, the role of pharmacotherapy for GAVE has been recognized. However, the evidence is limited to scattered case reports or small case series. This review comprehensively summarizes the efficacy and side effects of drugs commonly used for the treatment of GAVE, including octreotide, cyproheptadine, cyclophosphamide, prednisolone, estrogen-progesterone, thalidomide, bevacizumab, and tranexamic acid.

胃窦血管扩张症 (GAVE) 是一种罕见的临床实体，可导致胃肠道出血复发。关于 GAVE 的治疗没有达成共识。内窥镜治疗是首选的治疗选择，但复发率相当高。手术切除可以完全解决 GAVE，但具有侵入性，术后并发症的风险相对较高。最近，已经认识到药物治疗对 GAVE 的作用。然而，证据仅限于分散的病例报告或小病例系列。本综述全面总结了奥曲肽、赛庚啶、环磷酰胺、泼尼松龙、雌孕酮、沙利度胺、贝伐单抗和氨甲环酸等治疗GAVE常用药物的疗效和副作用。